el-GRen-US

 

Name of the medicinal product: OSTIREIN

Content: Each capsule contains 50 mg of Diacerein.

Pharmaceutical Form: Capsule

Pharmacotherapeutic group: Non-Steroidal Anti-Inflammatory and Antirheumatic / Interleukin-1 Inhibitors

Packaging Description: Cardboard box containing 30 hard capsules packed in PVC / PE / PVDC - Aluminum foil blister along with package leaflet.

Ostirein contains diacerein and is used to relieve the symptoms of osteoarthritis of the hip or knee.

It takes some time for Ostirein to work. Therefore, treatment with Ostirein is not recommended for a specific form of hip osteoarthritis known as rapid progressive (worsening) hip osteoarthritis. Patients with this form of the disease may have less benefit from the treatment.
Do not take Ostirein:
If you are allergic (hypersensitive) to diacerein or any of the ingredients of Ostirein.
If you have any liver problems or a history of liver problems
Warnings and precautions:
Check with your doctor before taking Ostirein if you have ever had liver disease.
Some patients may have loose stools or diarrhea after taking Ostirein. If diarrhea occurs while you are taking this medicine, stop Ostirein and talk to your doctor to discuss any other treatments available.
You should not take laxatives during treatment with Ostirein.
Some liver problems have been reported in some patients taking diacerein, including increased hepatic enzymes in the blood and hepatitis (inflammation of the liver). Your doctor may ask you to have blood tests to check it liver function.
Other medicines and Ostirein:
Tell your doctor or pharmacist if you are taking, have recently taken or will take other medicines.
Ostirein with food, drinks, and alcohol:
Drinking alcohol while taking Ostirein may increase the risk of liver damage. Alcohol consumption should be restricted while you are being treated with Ostirein.
Use in children and adolescents:
Ostirein should not be given to children under the age of 15 years.
Use in elderly patients:
Diacerein is not recommended for patients over 65 years of age..
Pregnancy and lactation:
Pregnancy:
You should tell your doctor if you think you are (or will be) pregnant. Normally, your doctor will advise you to take another medicine instead of Ostirein as Ostirein is not recommended during pregnancy because there is no experience of using it during pregnancy in humans.
Breastfeeding:
If you are breastfeeding, you should not take Ostirein, as it is reported in the literature the presence, in breast milk, in small proportions, of anthraquinone derivatives.
Driving and using machines
You will not notice any change in the ability to drive and use machines from using the product.
Important information about some of the ingredients of Ostirein
Ostirein contains lactose monohydrate. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

Like all medicines, Ostirein can cause side effects, although not everybody gets them.
Tell your doctor immediately and discontinue Ostirein treatment if abnormally frequent slurry or slurry occurs.
Tell your doctor immediately if you have abdominal pain, jaundice (yellow discoloration in the eyes or skin), constipation or itchy skin, as these may be signs of serious diseases such as liver disease.
Very common side effects (may affect more than 1 in 10 people treated):
- diarrhea,
- abdominal pain
Common side effects (may affect up to 1 in 10 people treated):
- frequent stools
- flatulence
- itching (itching), rash, eczema (red rash with itching).
Uncommon side effects (may affect up to 1 in 100 people):
- increase in blood enzyme levels in blood tests.
In some cases, diarrhea can be life-threatening complication such as fluid loss and electrolyte disturbances.

What OSTIREIN contains
The active substance is diacerein.
Each hard capsule of Ostirein 50 mg contains 50 mg of diacerein.
Excipients: Lactose monohydrate, Croscarmellose sodium, Silicon Dioxide, colloidal, Polyvidone, Magnesium stearate.
Empty capsule composition: Titanium dioxide, Quinoline yellow, Indigo carmine, Gelatine